On countings and enumerations of block-parallel automata networks

When we focus on finite dynamical systems from both the computability/complexity and the modelling standpoints, automata networks seem to be a particularly appropriate mathematical model on which theory shall be developed. In this paper, automata networks are finite collections of entities (the automata), each automaton having its own set of possible states, which interact with each other over discrete time, interactions being defined as local functions allowing the automata to change their state according to the states of their neighbourhoods. The studies on this model of computation have underlined the very importance of the way (i.e. the schedule) according to which the automata update their states, namely the update modes which can be deterministic, periodic, fair, or not. Indeed, a given network may admit numerous underlying dynamics, these latter depending highly on the update modes under which we let the former evolve. In this paper, we pay attention to a new kind of deterministic, periodic and fair update mode family introduced recently in a modelling framework, called the block-parallel update modes by duality with the well-known and studied block-sequential update modes. More precisely, in the general context of automata networks, this work aims at presenting what distinguish block-parallel update modes from block-sequential ones, and at counting and enumerating them: in absolute terms, by keeping only representatives leading to distinct dynamics, and by keeping only representatives giving rise to distinct isomorphic limit dynamics. Put together, this paper constitutes a first theoretical analysis of these update modes and their impact on automata networks dynamics

Complexity of fixed point counting problems in Boolean Networks

A Boolean network (BN) with $n$ components is a discrete dynamical system described by the successive iterations of a function $f:\{0,1\}^n \to \{0,1\}^n$. This model finds applications in biology, where fixed points play a central role. For example, in genetic regulations, they correspond to cell phenotypes. In this context, experiments reveal the existence of positive or negative influences among components: component $i$ has a positive (resp. negative) influence on component $j$ meaning that $j$ tends to mimic (resp. negate) $i$. The digraph of influences is called signed interaction digraph (SID), and one SID may correspond to a large number of BNs (which is, in average, doubly exponential according to $n$). The present work opens a new perspective on the well-established study of fixed points in BNs. When biologists discover the SID of a BN they do not know, they may ask: given that SID, can it correspond to a BN having at least/at most $k$ fixed points? Depending on the input, we prove that these problems are in $\textrm{P}$ or complete for $\textrm{NP}$, $\textrm{NP}^{\textrm{NP}}$, \textrm{NP}^{\textrm{#P}} or $\textrm{NEXPTIME}$. In particular, we prove that it is $\textrm{NP}$-complete (resp. $\textrm{NEXPTIME}$-complete) to decide if a given SID can correspond to a BN having at least two fixed points (resp. no fixed point).Comment: 43 page

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men